By D. P. Griswold Jr., W. R. Laster Jr., M. W. Trader, D. J. Dykes (auth.), Professor Dr. Hans-Jörg Senn (eds.)
H.-J. Senn Adjuvant Chemotherapy (ACT) of breast melanoma has now emerged as one of many arguable su):>jects in scientific and likewise experimental oncology. pushed through turning out to be frustration approximately stagnating therapy charges in breast melanoma [1,4] and encouraged by means of stylish demonstration of hugely healing results of adjuvant systemic remedy in animal versions [6, eleven] and in different youth neoplasias , researchers brought ACT to the first remedy of breast melanoma with nice wish a few 15 years in the past. After a primary wave of remoted "historic" trials with often restricted yet in a single case extraordinary good fortune [5, 9], a moment iteration of ACT reports used to be initiated by means of NSABP investigators and oncology facilities in Europe [2, 6, 13]. those trials have been good carried out statistically and diagnostically, and all within the early Nineteen Seventies integrated a surgical keep an eye on arm. Early and intermediate valuable results on relapse-free survival (RFS) after 2-3 years median commentary time then triggered a complete sequence of ACT stories in breast melanoma. those "third-gener ation" reports frequently seemed a few confident impact of ACT as a given truth, losing surgical keep watch over regimens and evaluating assorted ACT regimens, expectantly in a potential, randomized approach 1984 Fig. 1. The mushrooming of adjuvant experiences in breast melanoma XII advent [reviews in three, 14]. The "mushrooming" of ACT stories in breast melanoma over the past 10 and particularly five years is proven in Fig. 1, and it will get fairly bulky even for the insider to maintain on best of the multitude of occasionally conflicting data.
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Additional resources for Adjuvant Chemotherapy of Breast Cancer: Papers Presented at the 2nd International Conference on Adjuvant Chemotherapy of Breast Cancer, Kantonsspital St. Gallen, Switzerland, March 1 – 3, 1984
The data presented do not allow correlation with size. The PQCP has material available on almost 500 of the 782 BCDDP patients with in situ carcinomas. To date, all cases of in situ carcinoma with lymph node metastasis are intraductal carcinoma. No case of in situ lobular carcinoma has lymph node metastasis. 32 W. H. Hartmann My purpose is to establish the fact that screening can detect mammary carcinoma at a stage when the disease is localized and more amenable to simpler therapeutic strategies.
Malignant cells generally have an abnormal nuclear DNA content (see ), and a decreased genetic stability is thus widely assumed to be responsible for their phenotypic variability . However, epigenetic changes and altered regulatory mechanisms may also play an important role. , [4, 29, 89]), our information on phenotypically differing cell sub populations in tumors comes from analyses of cultured cell lines established from primary or metastatic tumors. However, given both the different microenvironmental conditions in cell culture and the frequent generation of phenotypic variants in malignant cell populations, such in vitro analyses hardly provide a faithful picture of the relative proportions and properties of cell subpopulations within individual tumors.
Vol. 96 © Springer·Verlag Berlin· Heidelberg 1984 Molecular and Cellular Mechanisms Underlying Ineffective Cancer Chemotherapy 19 However, this general term needs more precise definition. Although malignant tumors and leukemias in most cases derive from one single clone of cells [26, 69], there is clear evidence that by the time of detection and treatment of malignant disease the population of malignant cells is usually composed of multiple cell subpopulations differing with regard to many of the phenotypic properties that we have learned to recognize.