Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

This quantity is the complaints of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: uncomplicated technology and New scientific functions, held in Florence, Italy, on June 4-8, 2000, which keeps the culture of masking either uncomplicated and medical facets of prostaglandin and leukotriene study.

At this assembly specific emphasis used to be given to the capability software of the radical COX-2 inhibitors, the genetics of bronchial asthma on the subject of the construction of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.

Traditionally, as has been performed in earlier conferences of this sequence, a large amount of new fabric was once awarded and mentioned this yr, with specific consciousness given to the latest medical data.

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Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

This quantity is the complaints of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: uncomplicated technology and New medical functions, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of overlaying either simple and medical features of prostaglandin and leukotriene examine.

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The transcription factor Sp1 family members, Sp1 and Sp3, were found to bind to the GC-box (-120 to -115) in the L TC 4 S basal promoter region as well as the distal CACCC motif( -149 to -145), as determined by super-shift analysis with antisera against individual Sp 1 family members [14]. Besides Sp 1 and Sp3, the distal CACCC motif was also found in EMSA to bind recombinant erythroid Kruppel-like factor (EKLF) protein, which is the founding member ofthe Kruppel-like fami1y oftranscription factors [19].

The first is observed in the course oftissue-specific macrophage differentiation. Monocytes circulating in peripheral blood are the precursors for all tissue macrophages. They emigrate from the bloodstream, horne to various tissues, and differentiate in a tissue-specific fashion into mature tissue macrophages. Monocytes themselves contain predominantly cytosolic 5-LO [10]. Interestingly, this cytosolic distribution is preserved during the course of monocyte differentiation into peritoneal macrophages [6] as well as pulmonary interstitial macrophages [25].

Another general means by which 5-LO localization may influence metabolie function of the enzyme involves its eapacity to interaet with downstream enzymes. The major 5-LO product of alveolar macrophages is L TB 4 • Synthesis ofthis moleeule requires the hydrolysis of 5-LO-derived LTA4 by the enzyme LTA4 hydrolase. Preliminary data derived from both in situ (immunohistochemical staining of lung tissue) and ex vivo (immunofluoreseence microscopy and subcellular fractionation of isolated cells) studies indicate that in alveolar macrophages, LT~ hydrolase is found in both cytosolic and intranuclear compartments.

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