Annual reports in medicinal chemistry. / Volume 7 by Richard V Heinzelman; American Chemical Society. Division of

By Richard V Heinzelman; American Chemical Society. Division of Medicinal Chemistry

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4 7 5-HT-depleted animals have b e e n r e p o r t e d t o b e more a c t i v e t h a n c o n t r o l s under c o n d i t i o n s of e x t r a environmental s t i m u l a t i o n , p a r t i c u l a r l y “novel” s t i m u l a t i o n . 50 S e x u a l i t y - D e s p i t e o c c a s i o n a l d i s s e n t 5 I t h e r e can now b e l i t t l e doubt t h a t PCPA d r a m a t i c a l l y enhances s e x u a l i t y i n s u i t a b l e animal p r o t o c o l s . 52a PCPA h a s b e e n observed t o a c t i v a t e l o r d o s i s , a prime i n d i c a t o r of e s t r u s b e h a v i o r , i n o v a r i e c t o m i z e d r a t s t r e a t e d w i t h e s t r o gen and exposed t o a v i g o r o u s male a r t n e r .

K r p h y and F. K. Goodwin, Amer. J. , (1971). 79. H. K. H. Brodie, D. L. hrphy, F. K. Goodwin and W. E. , C l b . Pharmacol. , 2, 228 (1971 1. 80. F. K. Goodwin, D. L. Murphy, H. K. H. Brodie and W. E. , Biol. , 2, 341 (1970). 81. B. J. Carroll, C l h . Pharmacol. , l2, 743 (1971). 82. F. K. Goodwin, D. L. h n n e r and E. S. , lo, Part I, 751 (1971). 83. P. Lidbrink, G. Jonsson and K. Fuxe, Neuropharmacology, 522 (1971). 84. F. Sulser and E. Sanders-Bush, Annu. Rev. , 11, 209 (1971). 85. M. I.

Kupfer, J. Scott, A. Sjoerdsma and F, Snyder, Electroenceph. Clin. Neurophysiol. 3 , 529 (1969). E. Hartmann, R. Chung and C. Chien, Psychopharmacologia 114 (1971). A. J. Brunet, Biol. Psychiatry 1, 13 (1969). m, a, 45 Rudz i k, Fr i i s Depressants Chap. 4 A. D. B. Scharf and T. Tan, Arch. Gen. Psychiat. 3, 219 (1970). 9. Zimmerman, Current Therap. Res. 12, 18 (1971). 10. L. 0. Randall, W. Schallek, C. L. Scheckel, P. L. Stefko, R. F. Banzig e r , W. Pool and R. A. Moe, Arch. I n t . Phannacodyn.

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